The antidepressant effect of the Ac-D-Met-Pro-Arg-Gly tetrapeptide after its chronic and acute administration to rats

    loading  Checking for direct PDF access through Ovid


The antidepressant effect of the Ac-D-Met-Pro-Arg-Gly tetrapeptide (Ac-D-MPRG), an analogue of the C-terminal fragment of arginine-vasopressin, has been studied in the forced swimming test on rats of both sexes at an age of 70 days. The tetrapeptide was chronically intranasally administered at dose of 0.01 μg/kg from day 8 to day 14 and from day 3 to day 21 after birth or in a single dose 5 min prior to testing. We observed changes in the behavioral parameters affected by tetrapeptide. The most pronounced effect of Ac-D-MPRG was observed during chronic administration from day 8 to day 14 after birth. The duration of passive swimming significantly increased, and the immobilization time sharply decreased. These data indicate the absence of a state of behavioral depression. Our results suggested that exogenous administration of the arginine-vasopressin derivative exhibited a prolonged positive effect on animal behavior if it is performed at the most important period in the formation of the vasopressinergic system, namely, the second week of postnatal development.

Related Topics

    loading  Loading Related Articles