Effects of antenatal hypoxic stress of different etiologies on males: Correlation between behavioral patterns and changes in antioxidant protection activity and GABA metabolism

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Abstract

In this study, we investigated the effects of antenatal (on the 10th day of intrauterine development) hypoxic stresses of different etiologies (acute hypobaric and intermittent normobaric hypoxias) on the activity of the antioxidant protection system and GABA metabolism in the cerebrum of sexually mature male rats on the 57th day of their postnatal development, as well as on the correlation between these changes and behavioral activity. It was shown that suppression of the antioxidant protection system and activation of GABA catabolism is observed in males that survived either prenatal acute hypobaric hypoxia or intermittent normobaric hypoxia. Moreover, diverse changes in the behavioral activity that characterized the level of anxiety, emotional strain, and risk behavior, were recorded in the experimental groups.

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