Disturbances in the expression Of neuronal cell adhesion proteins NCAM. Clinical aspects

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The NCAM neuronal cell adhesion protein, with adhesion and signal functions, helps to perform two-way communication with the environment and plays an important role in the formation and development of the nervous system. Changes in the expression of this protein during antenatal and postnatal development result in the appearance of a number of psychological, neurological, and oncological diseases. We reviewed studies that showed disturbances in NCAM expression in neuropsychic (multiple sclerosis and Alzheimer's disease), psychological (schizophrenia and bipolar disorders), and oncological diseases.

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