Effect of nicotine on the activity of basic carboxypeptidases in rat brain regions and adrenal glands

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We studied the effects of acute treatment with nicotine on the activity of carboxypeptidase H and phenylmethylsulphonylfluoride-inhibited carboxypeptidase, the main carboxypeptidases that cleave arginine and lysine residues from the C-terminus of molecules-precursors of biologically active peptides. The results suggest that the changes in the activity of the enzymes studied may be one of mechanisms of regulation of the level of neuropeptides during the action of toxic doses of N-choline mimetics.

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