The relationship between the level of neuroactive steroids in the brain, behavior, and anxiety in male rats with different hormonal status

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Abstract

We investigated the levels of neuroactive steroids, behavior, and anxiety in the brains of male rats with different hormonal status. We revealed a correlation between motor and exploratory activities, emotionality, and anxiety and the concentrations of corticosterone, testosterone, and estradiol in the hypothalamus, hippocampus, amygdala, cingulated gyrus, and frontal cortex in intact male rats, as well as in animals with experimentally high or low levels of sex steroids. The correlation analysis confirmed the selective involvement of different brain structures and neuroactive steroids in brain functioning and behavioral adaptation.

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