Fragile X-associated tremor/ataxia syndrome-an older face of the fragile X gene

    loading  Checking for direct PDF access through Ovid

Abstract

Background

A 76-year-old man presented with an 8-year history of balance problems and a 2-year history of short-term memory loss. He had also been experiencing long-term problems with impotence and episodes of urinary incontinence, and had been managed for hypertension for 25 years. His medical history was otherwise unremarkable. Three of his grandchildren had been diagnosed with fragile X syndrome.

Investigations

Neurological examination, cognitive and neuropsychological testing, nerve conduction studies, MRI, and genetic testing.

Diagnosis

Fragile X-associated tremor/ataxia syndrome (FXTAS) resulting from a premutation (CGG repeat) expansion of the FMR1 gene.

Management

Explanation of the genetic ramifications of premutation carrier status for the FMR1 gene, and symptomatic treatment for the clinical difficulties experienced by the patient.

Related Topics

    loading  Loading Related Articles