Behavioral, cellular, and synaptic tagging frameworks


    loading  Checking for direct PDF access through Ovid

Abstract

HighlightsBehavioral tagging is a common mechanism in both rodents and humans.Behavioral and synaptic tagging require similar biological/temporal characteristics.Overlapping neuronal ensembles are important for achieving behavioral tagging.Synaptic tagging is a circuit-level mechanism underlying behavioral tagging.Behavioral tagging is the transformation of a short-term memory induced by a weak experience into a long-term memory through temporal association with a novel experience. This phenomenon was discovered to recapitulate synaptic tagging and capture at the behavioral level. Significant progress has been made in determining the molecular machinery associated with synaptic tagging and capture and behavioral tagging theories. However, the tag setting and recruitment of plasticity-related proteins that occur within the spatiotemporally constrained cell ensemble at the network level (cellular tagging) in the brain where multimodal sensory information is input are just beginning to be understood. Here, we review the evidence for behavioral tagging and the mechanism underlying memory allocation at the network level leading to the overlap of cell ensembles. We also discuss the functional significance of overlapping cell ensembles in association of standard Pavlovian conditioning and distinct memories. Finally, we describe the role of neuronal ensemble overlap in behavioral tagging.

    loading  Loading Related Articles