Association betweenCCDC132,FDX1andTNFSF13gene polymorphisms and the risk of IgA nephropathy

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Abstract

Aim:

Previous genome-wide association studies have identified multiple susceptibility loci for IgA nephropathy (IgAN); however, validation of these findings is still needed.

Methods:

We performed a case-control study among 347 Chinese Han IgAN patients and 310 ethnicity-matched controls. Twenty-two single nucleotide polymorphisms (SNPs) were genotyped and association analysis was performed.

Results:

We found three alleles for IgAN in patients: the allele “C” of rs2188404 in theCCDC132gene by recessive model (odds ratio (OR), 1.65; 95% confidence interval (CI), 1.10–2.48;P= 0.014) and additive model (OR, 1.29; 95% CI, 1.03–1.61;P= 0.024) analysis, respectively, the allele “A” of rs10488764 inFDX1gene by additive model (OR, 1.27; 95% CI, 1.00–1.61;P= 0.048) analysis, the allele “A” of rs3803800 inTNFSF13gene by recessive model (OR, 2.05; 95% CI, 1.16–3.62;P= 0.010) and additive model (OR, 1.35; 95% CI, 1.06–1.72;P= 0.013) analysis, respectively. However, the associations between these SNPs and the risk of IgAN were not significant when adjusted for age and sex. Additionally, we found polymorphisms of rs2188404, rs10488764 and rs3803800 were correlated with urine protein (UPRO), human serum albumin (HSA), total cholesterol (TC) and Lee's pathological grades.

Conclusion:

We did not find any positive association between these SNPs and the risk of IgAN after adjustment by age and sex, but did find a significant and strong correlation with relevant clinical pathological parameters. Our study may provide a new perspective to understanding the aetiology of IgAN.

SUMMARY AT A GLANCE

This case-control study was designed to assess the association between CCDC132, FDX1 and TNFSF13 gene polymorphisms and the risk of IgA nephropathy in Chinese Han population.

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