Microglia kill amyloid-β1-42 damaged neurons by a CD14-dependent process

    loading  Checking for direct PDF access through Ovid

Abstract

Activated microglia are closely associated with neuronal damage in Alzheimer's disease. In the present study, neurons exposed to low concentrations of amyloid-β1-42, a toxic fragment of the amyloid-β protein, were killed by microglia in a process that required cell–cell contact. Pre-treating microglia with polyclonal antibodies to the CD14 protein, or treating neurons exposed to amyloid-β1-42 with a CD14-IgG chimera, prevented the killing of amyloid-β1-42 damaged neurons by microglia. Moreover, microglia from CD14 null mice failed to kill amyloid-β1-42 damaged neurons. Increased neuronal survival was accompanied by a significant reduction in the production of interleukin-6 indicative of reduced microglial activation. These results indicate an important role for CD14 in the recognition and subsequent killing of amyloid-β damaged neurons by microglia.

Related Topics

    loading  Loading Related Articles