The primary objective of this study was to further characterize the role of sex, if any, in event-related potentials (ERPs). More specifically, we aimed to investigate sex sensitivity with respect to the P300 ERP. Each female and male study participant underwent an oddball paradigm electroencephalography ERP session. ERP data were subjected to preprocessing and postprocessing, as well as statistical analysis. The results of the study showed that men had larger P300 amplitudes on average for both low-probability and high-probability stimuli compared with women (P<0.001). Men also showed shorter P300 latencies on average than did women (P<0.001). Significant differences in ERPs between men and women were observed in this study. The results indicate the existence of sex sensitivity to the P300 ERP, which may be because of men eliciting higher response inhibition compared with women.