Pharmacotherapy for Treatment of Complex Regional Pain Syndrome: A Review

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Complex regional pain syndrome (CRPS) is an ill-defined, poorly understood disorder that causes significant morbidity in those who suffer from it. It is estimated that up to 20% to 35% of patients will remain incapacitated indefinitely and that only 20% to 30% of patients will be able to return to their previous full-time employment. A number of treatments, interventional and noninterventional, have been posited as possible therapies for CRPS. We discuss and review here the evidence-based rationale for pharmacologic therapy for CRPS.

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