The aim of this paper is to present a 13-year-old patient with bilateral lower limb paralysis and bladder incontinence rapidly progressive within a week. Spine magnetic resonance imaging (MRI) showed a giant epidural mass extending from C6 to T6 and involving soft tissue paraspinally. A surgical procedure was performed, and postoperative histopathologic examinations proved that the mass was B-cell lymphoblastic lymphoma. Preoperative symptoms were not relieved because of some complications, which occurred postoperative. Decreased blood platelets caused a serious coagulation function disorder and discontinuity hyperpyrexia postoperatively. The patient had a poor prognosis and died 1 month postoperatively. When B-cell lymphoma has a serious neurological deficit with bone morrow involvement, surgical treatment should be considered cautiously.