SINGLE NUCLEOTIDE POLYMORPHISMS (SNPS) ASSOCIATED WITH GLIOMA SURVIVAL

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Abstract

BACKGROUND: In 2012, using a genome-wide association study (GWAS) of UCSF Adult Glioma Study patients and replication in patients from the Mayo Clinic, TCGA and GliomaSE, we showed that a SNP in SSBP2 on chromosome 5 was associated with survival of glioblastoma (GBM) patients who received standard of care (SOC). Since then we have examined 41 SNPs that were potentially associated with survival after glioma diagnosis based on our preliminary results or published results of others. METHODS: The data set consisted of 401 patients with grade 2 or grade 3 astrocytic, oligodendroglial, or mixed oligoastrocytic tumors and 339 GBM patients not included in the previous GWAS. RESULTS: The SSBP2 minor allele was again associated with poorer survival among GBM patients who received SOC, but interestingly with improved survival among Grade 2 and Grade 3 patients. SNPs in another region of chromosome 5 were associated with GBM survival irrespective of whether or not the patients had SOC. Several other SNPs were significantly (p < 0.05) associated with survival of GBM or lower grade glioma. The results are currently being replicated in a similar sized group of patients from the Mayo Clinic. CONCLUSIONS: Inherited germline variation may influence glioma survival. SECONDARY CATEGORY: n/a.

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