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Using rare intracranial recordings from the posterior interhemispheric region of the human brain, we explored the oscillatory properties of the posteromedial cortex (PMC) during rest. The PMC is a core structure of the default mode network, which is known for its higher activity during the resting state. We found that resting PMC spectral power peaked in the theta band range (4–7 Hz) and was clearly distinguishable from adjacent cortical sites in the occipital lobe displaying peaks in the alpha band range (8–12 Hz). Additionally, the phase of PMC theta oscillations modulated the amplitude of ongoing high gamma (70–180 Hz) activity during the resting state. The magnitude of this cross-frequency modulation was shown to fluctuate at time scales comparable to those observed in functional neuroimaging studies of intrinsic functional connectivity networks (˜ 0.1 Hz). The difference of canonical oscillations in the PMC compared to its adjacent cortical sites conforms to functional specialization across anatomical boundaries. Such differences may reflect separate oscillatory preferences between networks that are functionally connected.□ Human posteromedial cortex (PMC) is the hub of default mode network. □ PMC displays strong theta band (3–7 Hz) oscillations at rest. □ Phase of PMC resting theta modulates the amplitude of high gamma activity. □ Theta/gamma cross-frequency modulation displays slow fluctuations at ˜ 0.1 Hz.