aCenter for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Valencia, SpainbDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USAcInstituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, Sant Joan d’Alacant, SpaindIndiana University Network Science Institute, Indiana University, Bloomington, IN 47405, USA
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Connectomics data from animal models provide an invaluable opportunity to reveal the complex interplay between structure and function in the mammalian brain. In this work, we investigate the relationship between structural and functional connectivity in the rat brain cortex using a directed anatomical network generated from a carefully curated meta-analysis of published tracing data, along with resting-state functional MRI data obtained from a group of 14 anesthetized Wistar rats. We found a high correspondence between the strength of functional connections, measured as blood oxygen level dependent (BOLD) signal correlations between cortical regions, and the weight of the corresponding anatomical links in the connectome graph (maximum Spearman rank-order correlation Symbol). At the network-level, regions belonging to the same functionally defined community tend to form more mutual weighted connections between each other compared to regions located in different communities. We further found that functional communities in resting-state networks are enriched in densely connected anatomical motifs. Importantly, these higher-order structural subgraphs cannot be explained by lower-order topological properties, suggesting that dense structural patterns support functional associations in the resting brain. Simulations of brain-wide resting-state activity based on neural mass models implemented on the empirical rat anatomical connectome demonstrated high correlation between the simulated and the measured functional connectivity (maximum Pearson correlation Symbol), further suggesting that the topology of structural connections plays an important role in shaping functional cortical networks.HighlightsStructural and functional brain connectivity is assessed in the rat cortex.Functional interactions are constrained by underlying structural connections.Densely connected anatomical motifs are enriched within functional communities.A computational model based on the rat connectome can generate realistic dynamics.