MULAN: Evaluation and ensemble statistical inference for functional connectivity


    loading  Checking for direct PDF access through Ovid

Abstract

Many analysis methods exist to extract graphs of functional connectivity from neuronal networks. Confidence in the results is limited because, (i) different methods give different results, (ii) parameter setting directly influences the final result, and (iii) systematic evaluation of the results is not always performed. Here, we introduce MULAN (MULtiple method ANalysis), which assumes an ensemble based approach combining multiple analysis methods and fuzzy logic to extract graphs with the most probable structure. In order to reduce the dependency on parameter settings, we determine the best set of parameters using a genetic algorithm on simulated datasets, whose temporal structure is similar to the experimental one. After a validation step, the selected set of parameters is used to analyze experimental data. The final step cross-validates experimental subsets of data and provides a direct estimate of the most likely graph and our confidence in the proposed connectivity. A systematic evaluation validates our strategy against empirical stereotactic electroencephalography (SEEG) and functional magnetic resonance imaging (fMRI) data.HighlightsAn ensemble based approach combining multiple analysis methods and using fuzzy logic to extract graphs with the most probable structure.A genetic algorithm to obtain the best set of parameters.Cross-validation step to evaluate confidence in the computed graph.Worked examples using empirical stereotactic electroencephalography (SEEG) and functional magnetic resonance imaging (fMRI) data.Sensitivity analysis and computational time cost.

    loading  Loading Related Articles