A hitchhiker's guide to lesion-behaviour mapping

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Lesion-behaviour mapping is an influential and popular approach to anatomically localise cognitive brain functions in the human brain. Multiple considerations, ranging from patient selection, assessment of lesion location and patient behaviour, spatial normalisation, statistical testing, to the anatomical interpretation of obtained results, are necessary to optimize a lesion-behaviour mapping study and arrive at meaningful conclusions. Here, we provide a hitchhiker's guide, giving practical guidelines and references for each step of the typical lesion-behaviour mapping study pipeline.HIGHLIGHTSThe lesion method is an influential and popular method to study human brain function.But virtually no papers or books exist to assist scientists interested in this method.We here provide a hitchhiker's guide with practical guidelines and references.

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