p,p'-DDT-induced neurotoxic syndrome: Experimental myoclonus

    loading  Checking for direct PDF access through Ovid


Article Abstract

p, p'-DDT (100 to 600 mg per kilogram orally) produced spontaneous and stimulus-sensitive myoclonus in mice and rats. Drugs that enhance brain serotonergic activity reduced p, p'-DDT-induced myoclonus, and serotonin antagonists invariably aggravated this syndrome. p, p'-DDT-treated rats had increased concentrations of 5-hydroxyindoleacetic acid (5-HIAA) in seven regional areas, but serotonin was increased only in the midbrain and cerebellum. We postulate that p, p'-DDT-induced myoclonus may be causally related to blockade of serotonin receptors or inhibition of serotonin release into the synapse, resulting in functional deficiency of this neurotransmitter at the receptor site.

Related Topics

    loading  Loading Related Articles