Gamma hydroxybutyrate in the monkey IV. Dopaminergic mechanisms

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Article abstract

The electrical seizure activity and trancelike state induced in the rhesus monkey by gammahydroxybutyrate (GHB) were abolished by dextroamphetamine. Dextroamphetamine blockade of this neurophysiologic effect was overcome with chlorpromazine, a dopamine receptor blocker. These results suggest that the electroencephalographic (EEG) and behavioral effects of GHB are related to effects on dopaminergic systems. Such a relationship, if substantiated by further studies, might indicate that anticonvulsant drugs used to treat petitma1 epilepsy have a dopaminergic mode of action.

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