Bedside evaluation of large motor units in childhood spinal muscular atrophy

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One hundred patients with motor unit disease were examined to determine the diagnostic reliability of several clinical signs of large motor units. These signs were high-intensity, low-pitched rumbling on skeletal muscle auscultation, voluntary contraction fasciculations, contraction fasciculation trembling, and palpable contraction fasciculations. Among 22 cases of spinal muscular atrophy, contraction fasciculation trembling wa noted in 86 percent, abnormal muscle percent, and voluntary contraction fasciculations in 50 percent.

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