Ifosfamide causes a diazepam-sensitive encephalopathy

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Article abstract

An encephalopathy characterized by confusion, stupor, and mutism frequently occurs during administration of the chemotherapeu-tic drug ifosfamide (IFX). We investigated two patients who developed encephalopathy during IFX infusion. Both exhibited a rapid and near-complete restoration of baseline mental status functioning concurrent with EEG improvement after administration of intravenous diazepam. We recommend an EEG and trial of benzodiazepines in patients with IFX encephalopathy.

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