Heightened intrathecal release of proinflammatory cytokines in Creutzfeldt-Jakob disease

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Article abstract

The authors report high intrathecal release of tumor necrosis factor alpha (TNF-α) and interleukin (IL)-1β in five patients with sporadic or new-variant Creutzfeldt-Jakob disease (CJD) without activation of the humoral or lymphocytic immune responses. Increased release of TNF-α and IL-1β was also detected in some patients with progressive dementias. CJD is associated with a local cerebral host response that involves the release of proinflammatory cytokines.

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