Influence of the amyloid precursor protein locus on dementia in Down syndrome

    loading  Checking for direct PDF access through Ovid

Abstract

Background:

The amyloid precursor protein (APP) locus on chromosome 21 influences the development of Alzheimer disease.

Method:

The authors investigated the relationship between a tetranucleotide repeat on intron 7 of the APP gene and the age at onset of dementia in Down syndrome (DS).

Results:

There was a 13-year difference in the age at onset of dementia in DS associated with the number of tetranucleotide repeat alleles in APP.

Conclusion:

APP is an important locus predicting the age at onset of dementia in people with Down syndrome.

Related Topics

    loading  Loading Related Articles