Annexin V SPECT imaging of phosphatidylserine expression in patients with dementia

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The authors sought to use radiolabeled annexin V, a marker of phosphatidylserine expression, to image Alzheimer dementia (AD). Four of five patients with AD had multifocal cortical annexin V uptake, whereas all seven non-AD and six control patients had normal SPECT. The mean cortex/cerebellar activity in patients with AD (1.4 ± 0.6) was higher than that of non-AD dementia patients (0.7 ± 0.2; p = 0.02). Radiolabeled annexin V may be useful for imaging AD.

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