Neural correlates of disturbed perception of verticality

    loading  Checking for direct PDF access through Ovid

Abstract

Objective:

Perception of verticality can be perturbed after cortical stroke. However, a relationship between lesion location and pathologic perception of verticality is still a matter of debate since previous studies revealed contradictory results. Thus, the aim of the current study was to test whether specific cortical lesions were associated with tilts of subjective visual vertical (SVV) and to determine the critical brain areas that cause such tilts in the case of a lesion.

Methods:

SVV was systematically studied in 54 patients (22 patients with left-sided and 32 patients with right-sided lesions) with acute unilateral strokes, analyzed by modern voxel-wise lesion-behavior mapping techniques.

Results:

The data give evidence for an association between tilt of SVV and the insular cortex (IC) and inferior frontal gyrus (IFG) in both hemispheres. Whereas the IC seems to be the prominent structure in the left hemisphere, the IFG is most affected in the right hemisphere. Furthermore, other cortical regions such as the superior temporal gyrus (STG) and the rolandic operculum as well as—subcortically—the inferior occipitofrontal fascicle and the superior longitudinal fascicle seem to be involved in the vestibulo-cortical network for the perception of verticality in the roll plane.

Conclusion:

Damage to these regions might lead to an imbalance within the vestibular network of one hemisphere due to a deficit in multimodal signal processing.

GLOSSARY

CoC: Center of Cancellation

GLOSSARY

DWI: diffusion-weighted imaging

GLOSSARY

FDR: false discovery rate

GLOSSARY

FLAIR: fluid-attenuated inversion recovery

GLOSSARY

IC: insular cortex

GLOSSARY

IFG: inferior frontal gyrus

GLOSSARY

IOF: inferior occipitofrontal fascicle

GLOSSARY

IPL: inferior parietal lobule

GLOSSARY

MCA: middle cerebral artery

GLOSSARY

OTR: ocular tilt reaction

GLOSSARY

PIVC: parieto-insular vestibular cortex

GLOSSARY

SLF: superior longitudinal fascicle

GLOSSARY

SOF: superior occipitofrontal fascicle

GLOSSARY

STG: superior temporal gyrus

GLOSSARY

SVV: subjective visual vertical

GLOSSARY

VLBM: voxelwise lesion-behavior mapping

GLOSSARY

VOR: vestibulo-ocular reflex

Related Topics

    loading  Loading Related Articles