Drosophila melanogasteras a genetic model system to study neurotransmitter transporters

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HighlightsDrosophila express orthologs of most mammalian neurotransmitter transporters.Fly genetics provides a powerful tool-set to explore transporter function in vivo.Screens for genes and drugs that modify transport function are possible in the fly.The model genetic organism Drosophila melanogaster, commonly known as the fruit fly, uses many of the same neurotransmitters as mammals and very similar mechanisms of neurotransmitter storage, release and recycling. This system offers a variety of powerful molecular-genetic methods for the study of transporters, many of which would be difficult in mammalian models. We review here progress made using Drosophila to understand the function and regulation of neurotransmitter transporters and discuss future directions for its use.[]

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