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Conduction block is one of the most important physiological consequences of demyelination, alerting the examiner to a condition amenable to treatment. Its diagnosis is complicated by the phase cancellation as well as many other physiological and technical factors. Conduction block can be reversed not only by measures increasing action current but also by lowering the threshold for excitation with digitalis. Multifocal motor neuropathies with conduction block can mimic a motor neuron disease, yet can be treated by immunosuppressive agents.