Current Opinion in Neurology. 9(3):165–177, JUNE 1996
PMID: 8839607
Issn Print: 1350-7540
Publication Date: June 1996
The immunopathogenesis of multiple sclerosis and Guillain-Barré syndrome
Gavin Giovannoni;Hans-Peter Hartung;
+ Author Information
Department of Neuroimmunology, Institute of Neurology, Queen Square, London*the Department of Neurology, Julius-Maximilians University, Würzburg, Germany
Abstract
This review covers current hypotheses regarding antigen-specific disease induction, immune responses within the central and peripheral nervous systems, the nonspecific inflammatory cascade, and mechanisms responsible for demyelination, axonal loss, and disease progression in multiple sclerosis and Guillain-Barré syndrome. We also discuss the new evidence on the role of infection as an aetiological factor in multiple sclerosis and Guillain-Barré syndrome.
