Impact of addictive and harmful substances on fetal brain development

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Animal models of alcohol, nicotine, and cocaine exposure have provided convincing evidence for prenatal effects on brain development caused by alterations in cell migration, signal transduction, and neurotransmitter function. The extrapolation to effects on the human nervous system is confounded by the multiplicity of factors affecting central nervous system development. Curr Opin Neurol 12:161-166.

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