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It is evident that the eases of diffuse sclerosis form a heterogenous group; in some of these cases metachromatic materials may be observed. These metachromatic materials are not a single substance hut a group of substances with properties which vary from case to case, and even within the same case. It is possible that in some instances they represent an abnormal intermediate in myelin formation. Metachromatic materials may also be observed in the brain in circumstances not obviously related to diffuse sclerosis or demyelinization. The pathogenesis and metabolic relationships of diffuse sclerosis remain to be clarified.