STUDIES OX KERNICTERUS: RELATIONSHIP WITH SULFONAMIDE INTOXICATION, REPORT ON KERNICTERUS IN RATS WITH GLUCURONYL TRANSFERASE DEFICIENCY AND REVIEW OF PATHOGENESIS


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Abstract

SUMMARYThe elinieopathological syndrome of kernieterus observed in rats with congenital hypoglucuronyltransferasia (Gunn's strain of rats) is similar to the syndrome of human kernieterus.The earliest detectable changes in ganglion cells are associated with the presence of intracellular bilirubin.Sulfonamides, do not produce kernieterus in normal newborn nits, nor do they alter the blood-brain barrier.Their deleterious effect in Gunn's strain of nits and in premature infants may be explained by the displacement of bilirubin from the blood compartment into the extracellular fluid. It is suggested that a similar mechanism may be operative in kernicterus occurring under other circumstances.The toxic unconjugated bilirubin is probably the cause of central nervous system damage.

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