Heterogeneity of the Mechanisms of Nerve Cell Damage in Demyelinating Autoimmune Diseases of the CNS

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The current state of questions of neurodegeneration in demyelinating autoimmune diseases is reviewed. Experimental and clinical evidence for heterogeneity in the mechanisms of nervous tissue destruction is presented. Interactions between neuroinflammatory processes, excitotoxicity, and oxidative stress in producing damage to oligodendrocytes (myelin) and neurons (axons) are addressed.

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