The Role of Erythropoetin in Ischemic Preconditioning, Postconditioning, and Regeneration of the Brain after Ischemia


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Abstract

Analysis of published data shows that erythropoietin plays an important role in controlling the tolerance of the brain to the actions of ischemia and reperfusion. This cytokine has a role in ischemic preconditioning of the brain and can imitate the phenomena of preconditioning and postconditioning. However, it is unclear whether endogenous erythropoietin is involved in postconditioning of the brain. Erythropoetin was found to inhibit neuron apoptosis after ischemia/reperfusion. Erythropoetin can stimulate brain regeneration after stroke. The signaling mechanism of the neuroprotective action of erythropoietin has been well studied, though there are very few data on the mechanisms of erythropoietin-induced neurogenesis and neoangiogenesis. It is not known whether erythropoietin has infarct-limiting effects in humans or can stimulate neurogenesis and neoangiogenesis in patients after stroke.

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