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In this study, we want to present the first case of thoracolumbar myxopapillary ependymoma and cervical meningotheliomatous meningioma in the patient with spinal cord injury. Because of early diagnosis and proper rehabilitation program patient's ability to walk independently is very well developed. A 66-year-old woman with lower extremity paralysis underwent further examination that revealed T12-L1 intradural-extramedullary tumor and was operated for myxopapillary ependymoma. As she had another attack of muscular weakness during home rehabilitation program. Owing to upper extremity weakness and muscle atrophy, cervical magnetic resonance imaging scan was performed and a C3-T1 extradural extensive tumor was detected. After neurosurgical consultation, the tumor (meningotheliomatous meningioma) was totally excited. After having been operated for 2 different kind of tumor at 2 different part of the spinal cord, the patient improved well with rehabilitation to be able to walk with a walker and then normally in the subsequent follow-up. We can emphasize the importance of detailed historical evaluation of patients and complete physical and neurologic examination in order not to overlook important clinical pathologies signs and symptoms.