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Dyke-Davidoff-Masson Syndrome (DDMS), also called cerebral hemiatrophy, is a clinical condition characterized by hypoplasia or atrophy of one of the cerebral hemispheres during the fetal period or early childhood, accompanied by seizures, facial asymmetry, contralateral hemiplegia or hemiparesis, and learning difficulties. The description of DDMS has been used in the presence of associated radiologic findings. In this paper, we present 2 siblings: one admitted to our hospital with seizures and diagnosed with DDMS and the other with a history of seizures, similar presentation of a neurologic examination and electrophysiology testing, but with normal results on magnetic resonance imaging. We present these cases to demonstrate similar symptoms and physical and electrophysiologic features in 2 siblings with similar clinical presentations with different magnetic resonance imaging findings.