Hysteresis in the Relationship between Cerebrospinal Fluid Absorption Minus Formation and Cerebrospinal Fluid Pressure in the Dog

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Abstract

In this study the difference between cerebrospinal fluid (CSF) absorption and formation (A - F) was measured as a function of CSF pressure in the living and dead dog. We determined this relationship between A - F and CSF pressure during both increasing and decreasing CSF pressures. A hysteresis effect was identified in 78% of living animals, but was not seen in the dead animals. This suggests that the mechanism of CSF absorption in the living dog is nonpassive and pressure-sensitive.

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