Variation in Patient Characteristics and Outcomes Between Early and Delayed Surgery in Poor-Grade Aneurysmal Subarachnoid Hemorrhage

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Abstract

BACKGROUND:

There is no consensus regarding the optimal timing for surgery for poor-grade aneurysmal subarachnoid hemorrhage.

OBJECTIVE:

To retrospectively evaluate variation in patient characteristics and outcomes between early and delayed surgery groups.

METHODS:

Poor-grade aneurysmal subarachnoid hemorrhage was defined as a World Federation of Neurosurgical Societies grade of IV or V after resuscitation. Early surgery was defined as surgery performed within 72 hours of ictus, and delayed surgery was defined as surgery after 72 hours. Outcomes were assessed by modified Rankin score. The mean time of follow-up was 12.5 ± 3.4 months.

RESULTS:

Of the 118 patients included in the study, 80 (68%) underwent early surgery and 38 (32%) underwent delayed surgery. Patients with brain herniation (P < .001) and a lower Fisher grade (P = .02) more often underwent early surgery. Patients in the early group more often underwent decompressive craniectomy (P < .001). Postoperative complications and length of hospital stay did not differ, and outcomes were similar between the 2 groups. Forty (34%) patients had an excellent outcome (modified Rankin score 0-1). Multivariate analysis showed a slight trend toward an excellent outcome in the early surgery group. Younger age, World Federation of Neurosurgical Societies grade IV after resuscitation, and middle cerebral artery aneurysms were independent predictors of an excellent outcome.

CONCLUSION:

Although patients with brain herniation and a lower Fisher grade were more likely to undergo early surgery, there was a slight trend toward an excellent outcome in the early surgery group. Patients with a younger age, World Federation of Neurosurgical Societies grade IV after resuscitation, and middle cerebral artery aneurysms were more likely to experience an excellent outcome.

ABBREVIATIONS:

aSAH, aneurysmal subarachnoid hemorrhage

ABBREVIATIONS:

CI, confidence interval

ABBREVIATIONS:

DC, decompressive craniectomy

ABBREVIATIONS:

ICH, intracerebral hematoma

ABBREVIATIONS:

IVH, intraventricular hemorrhage

ABBREVIATIONS:

MCA, middle cerebral artery

ABBREVIATIONS:

mRS, modified Rankin score

ABBREVIATIONS:

OR, odds ratio

ABBREVIATIONS:

WFNS, World Federation of Neurosurgical Societies

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