Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on Pathological Methods and Prognostic Factors in Vestibular Schwannomas


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Abstract

TARGET POPULATIONAdults diagnosed with vestibular schwannomas.QUESTION 1What is the prognostic significance of Antoni A vs B histologic patterns in vestibular schwannomas?RECOMMENDATIONNo recommendations can be made due to a lack of adequate data.QUESTION 2What is the prognostic significance of mitotic figures seen in vestibular schwannoma specimens?RECOMMENDATIONNo recommendations can be made due to a lack of adequate data.QUESTION 3Are there other light microscopic features that predict clinical behavior of vestibular schwannomas?RECOMMENDATIONNo recommendations can be made due to a lack of adequate data.QUESTION 4Does the KI-67 labeling index predict clinical behavior of vestibular schwannomas?RECOMMENDATIONNo recommendations can be made due to a lack of adequate data.QUESTION 5Does the proliferating cell nuclear antigen labeling index predict clinical behavior of vestibular schwannomas?RECOMMENDATIONNo recommendations can be made due to a lack of adequate data.QUESTION 6Does degree of vascular endothelial growth factor expression predict clinical behavior of vestibular schwannomas?RECOMMENDATIONNo recommendations can be made due to a lack of adequate data.The full guideline can be found at: https://www.cns.org/guidelines/guidelines-management-patients-vestibular-schwannoma/chapter_6.

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