Unawareness of Cognitive Impairments in Alzheimer's Disease

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We compared patients with Alzheimer's disease (AD) who were unaware of their cognitive impairments to AD patients who were aware of their deficits. The two groups did not differ in sex, age, education, or premorbid intelligence. Although the groups did not differ in dementia severity, memory function, or language ability, the unaware group demonstrated significantly poorer visuoconstructive ability. We conclude that unawareness of cognitive impairments in AD is accompanied by prominent visuoconstructive dysfunction and suggest that this reflects extensive involvement of the right cerebral hemisphere by the neurodegenerative process.

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