Membranotropic properties of latrotoxin-like protein: Studies on liposomes

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Abstract

Fusion and changes in permeability of artificial phospholipid vesicles (liposomes) caused by the influence of α-latrotoxin-like protein (L protein) from the gray matter of the bovine brain were studied using a hydrophobic fluorescent probe, R18. It was shown that L protein stimulates fusion of negatively charged liposomes. This effect becomes stronger in acidified media. The influence of L protein on the permeability of phosphatidylcholine liposome membrane is also a pH-dependent process.

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