Effect of an extract from embryonic neural tissue on the content of dopamine and noradrenaline in explants of the midbrain and medulla of newborn rats

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Abstract

It was found that addition of an extract from embryonic neural tissue (ENT), which contained 150 μg/ml proteins, to the culture medium favored viability of catecholaminergic neurons in cultured explants of the midbrain and medulla of newborn rats and establishment of contacts among these neurons. Addition of the ENT extract increased the dopamine level, measured at the 3rd-4th days of culturing, in the explants of the midbrain and medulla by 1.5 and 3.8 times, respectively. Similar indices for noradrenaline in the above structures were 2.5–2.6 times. The content of cAMP and cGMP in the explants increased 2.3 and 2.8 times, respectively, already 2–3 h after the ENT extract addition.

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