Cellular mechanisms underlying the development of diabetic neuropathies

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Abstract

The data of recent studies of fundamental mechanisms underlying the development of diabetic neuropathies are summarized in the Review. The importance of a sorbitol-polyol pathway of glucose metabolism, as well as the roles of production of peroxide radicals and activation of the processes of non-enzymatic glycosilation in the nerve cells are analyzed. Special attention is paid to the roles of growth factors in morphological modifications of the neuronal structures and to that of intracellular signalization in functional disturbances in the nerve cells. Changes in intracellular homeostasis of Ca ions are of considrable importance for the development of peripheral diabetic neuropathies.

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