Conditioned reflex-related plasticity in the neocortex

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The spike activity of neurons of the sensorimotor cortex was analyzed in cats before, during, and after iontophoretic application of substances influencing synaptic transmission. It was shown that, in addition to glutamate ionotropic receptors, glutamate metabotropic receptors, as well as adrenergic and dopaminergic receptor systems, are involved in plastic rearrangements of synaptic connections among neocortical neurons. The pattern of aftereffects allows us to suppose that potentiation of synaptic events during conditioned reflex-related learning can be maintained for 10 to 20 min, an interval sufficient for consolidation of a memory track.

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