Post-traumatic metabolic shifts and epileptogenic plasticity in the CNS

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Metabolic and ultrastructural disturbances in the brain tissues, which developed within a remote period after light craniocerebral trauma, and their dependence on the dynamics of formation of a post-traumatic epileptic nidus (EN), were studied in the experiments on rabbits. Manifestations of disturbances in energy metabolism (tissue respiration, oxidative phosphorylation, and ATP synthesis), activation of the antioxidant glutathione system, modification of the membrane phospholipid composition, and marked activation of epileptogenic-type plastic processes were revealed in the EN tissues.

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