Expression of Erythropoietin mRNA in the Brainstem of Rats Adapted to Intermittent Hypoxia

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Abstract

We studied the content of mRNA of a glycoprotein, erythropoietin, in structures of the rat brainstem; the animals were adapted to intermittent hypoxia at different contents of oxygen in hypoxic gas mixtures (12 or 7% O2, a 2-week-long course with five sessions per day). Under conditions of such adaptation, the content of erythropoietin in the brainstem demonstrated a clear trend toward a decrease after a course of moderate hypoxic trainings (12% O2), and a more than twofold drop after a “stronger” course (7% O2). We suppose that the decrease in the intensity of synthesis of this glycoprotein

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