Cardiac Valvular Disease Associated with the Dopamine Agonists Pergolide and Cabergoline

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Two large independent studies raise further concern over increased risk of serious cardiac valve disease in patients treated for Parkinson's disease with ergoline dopamine agonists, pergolide and cabergoline.


Schade R, et al. Dopamine Agonists and the Risk of Cardiac-Valve Regurgitation. N Engl J Med. 2007;356:29-38. Zanettini R. et al. Valvular Heart Disease and the Use of Dopamine Agonists for Parkinson's Disease. N Engl J Med. 2007;356:39-46.

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