Cardiac Valvular Disease Associated with the Dopamine Agonists Pergolide and Cabergoline

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Abstract

Synopsis:

Two large independent studies raise further concern over increased risk of serious cardiac valve disease in patients treated for Parkinson's disease with ergoline dopamine agonists, pergolide and cabergoline.

Sources:

Schade R, et al. Dopamine Agonists and the Risk of Cardiac-Valve Regurgitation. N Engl J Med. 2007;356:29-38. Zanettini R. et al. Valvular Heart Disease and the Use of Dopamine Agonists for Parkinson's Disease. N Engl J Med. 2007;356:39-46.

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