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Synopsis:Genome sequencing and analysis of mutations of the TREM2 gene demonstrated that homozygotes have an increased risk of developing Alzheimer's disease, and carriers have cognitive impairments compared to age-matched controls.Sources: Jonsson T, et al. Variant of TREM2 associated with the risk of Alzheimer's disease. N Engl J Med 2013;368:107-116.Guerreiro R, et al. TREM2 varients in Alzeimer's disease. N Engl J Med 2013;368:117-127.