Autoantibodies to N-methyl-D-aspartate Receptor Found in Some Adults with Herpes Simplex Encephalitis: Are They Significant?

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Synopsis:Some patients with herpes simplex encephalitis develop autoantibodies against N-methyl-Daspartate receptors. Sera from these patients cause a downregulation of neuronal synaptic markers in vitro, suggesting a potential pathogenic disease-modifying effect.

Source: Pruss H, et al. N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis. Ann Neurol 2012;72:902-911.

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