Back to the Vascular Theory of Migraine?

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Synopsis:Nitric oxide donor vasoactive compounds may trigger migraine headaches in migraineurs by promoting a massive increase in the mechanosensitivity of meningeal nociceptors, through an intermediate vasodilatory effect on meningeal vasculature.

Source: Zhang X, et al. Vascular extracellular signal-regulated kinase mediates migraine-related sensitization of meningeal nociceptors. Ann Neurol 2013;73:741-750.

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