Cerebrospinal Fluid β-Amyloid 42 vs Amyloid PET Imaging in the Diagnosis of Alzheimer’s Disease

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Aβ 42, measured in cerebrospinal fluid, may help determine whether patients have normal or increased cortical Aβ deposition. Additionally, abnormal PET 18F-flutemetamol retention levels correlate with disease stage in patients with mild cognitive symptoms.


Palmqvist S, et al. Accuracy of brain amyloid detection in clinical practice using cerebrospinal fluid β-Amyloid 42: A cross-validation study against amyloid positron emission tomography. JAMA Neurology 2014;71:1282-1289. doi:10.1001/jamaneurol.2014.1358.

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